| Connectivity | 576 |
|---|---|
| Notes | This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. |
| Hugo ID | 6973 |
| Name | MDM2 |
| Description | transformed mouse 3T3 cell double minute 2 |
| URN | urn:agi-llid:4193 |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleolus | |
| nucleus | |
| ubiquitin ligase complex | |
| nucleoplasm |
| Cell Localization | Nucleus |
|---|
| GO Biological Process | cell growth and/or maintenance |
|---|---|
| protein catabolism | |
| protein ubiquitination | |
| traversing start control point of mitotic cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of transcription from Pol II promoter | |
| protein complex assembly | |
| regulation of cell cycle | |
| regulation of protein catabolism |
| EC Number | 6.3.2.- |
|---|
| State | mouse double minute 2 homolog isoform MDM2 |
|---|---|
| mouse double minute 2 homolog isoform MDM2a | |
| mouse double minute 2 homolog isoform MDM2b | |
| mouse double minute 2 homolog isoform MDM2c | |
| mouse double minute 2 homolog isoform MDM2d | |
| mouse double minute 2 homolog isoform MDM2e |
| State Description | Transcript Variant: This variant (MDM2) is expressed in colon and muscle. It represents the longest transcript and encodes the longest isoform (MDM2), that contains a p53 binding domain, a nuclear localization signal, a zinc coordinating RNA binding do... |
|---|---|
| Transcript Variant: This variant (MDM2a) is expressed in lympocytes. It lacks three exons and a segment in the 3' coding region, as compared to variant MDM2. The resulting isoform MDM2a, also known as isoform KB9, lacks a nuclear localization signal an... | |
| Transcript Variant: This variant (MDM2b) is expressed in lung. It lacks multiple exons and two segments in the 3' coding region, as compared to variant MDM2. The resulting isoform MDM2b, also known as isoform L1_15, lacks a nuclear localization signal,... | |
| Transcript Variant: This variant (MDM2c) is expressed in intestine. It has an additional exon in the 5' coding region and lacks multiple exons and a segment in the 3' region, as compared to variant MDM2. The additional exon introduces a stop codon and ... | |
| Transcript Variant: This variant (MDM2d) is expressed in lymphocyte. It lacks several exons and two segments in the 3' coding region, as compared to variant MDM2. The resulting isoform MDM2d, also known as isoform HB67, lacks a nuclear localization sig... | |
| Transcript Variant: This variant (MDM2e) is expressed in kidney. It lacks multiple exons and a segment in the 3' coding region, as compared to variant MDM2. The resulting isoform MDM2e, also known as isoform N1_40, lacks a nuclear localization signal a... |
| MGI ID | 96952 |
|---|
| Swiss-Prot Accession | Q00987 |
|---|
| OMIM ID | OMIM:164785 |
|---|
| Alias | Mdm2 |
|---|---|
| mouse double minute 2 | |
| Mdm-2 | |
| transformed mouse 3T3 cell double minute 2 | |
| GNB:6754672 | |
| p53 binding protein MDM2 | |
| MDM2_MOUSE | |
| Ubiquitin-protein ligase E3 Mdm2 | |
| 1700007J15Rik | |
| hdm2 | |
| Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | |
| p53-binding protein MDM2 | |
| mouse double minute 2, human homolog of; p53-binding protein | |
| PIR:S24354 | |
| MGC71221 | |
| double minute 2 homolog full length protein isoform | |
| double minute 2 homolog isoform MDM2a | |
| double minute 2 homolog isoform MDM2b | |
| double minute 2 homolog isoform MDM2c | |
| double minute 2 homolog isoform MDM2d | |
| double minute 2 homolog isoform MDM2e | |
| Double minute 2 protein | |
| mouse double minute II | |
| Oncoprotein Mdm2 | |
| transformed mouse 3T3 cell double minute II | |
| mouse double minute 2 homolog MDM2a | |
| mouse double minute 2 homolog MDM2b | |
| mouse double minute 2 homolog MDM2c | |
| mouse double minute 2 homolog MDM2d | |
| mouse double minute 2 homolog MDM2e | |
| mouse double minute 2 homolog full length |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 246362 |
|---|---|
| 17246 | |
| 69330 | |
| 103091 | |
| 4193 |
| RGD ID | 70489 |
|---|
| Pathway | p53 Signaling |
|---|---|
| ATM signaling | |
| moduleb_direct interactions | |
| moduleb_shortest paths | |
| moduleb_commontarget-complex | |
| moduleb_commontargets-functionalclass | |
| moduleb_commontarget_cell processes | |
| moduleb_proteins | |
| moduled_direct interactions | |
| moduled_shortest paths | |
| moduled_proteins | |
| moduled_complex | |
| moduled_functional class | |
| moduled_cell process |
| Unigene ID | Mm.22670 |
|---|---|
| Hs.212217 |
| Group | protein binding |
|---|---|
| metal ion binding | |
| moduleb | |
| moduled |