damage DNA damage recognition relaxation drug resistance fate senescence DNA nucleotide-excision repair amplify s phase protein degradation assemble exocytosis g2-m transition focal contact phagocytosis inflammation contraction shape DNA protection chemosensitivity dna fragmentation detachment immunoreactivity transformation regulation of signal transduction G1-S transition differentiation maturation RNA localization death stability g1 phase mitogenesis embryonic development apoptosis transduction angiogenesis mitosis proliferation accumulation oncogenesis invasion PIP3 secretion remodeling cell survival motility MDM2 TP53 AKT1 PTEN pregnancy RNA elongation distribution morphogenesis response to DNA damage metabolism reorganize regenerate myogenesis sensitized condense DNA recombination axis integrity synthesis steroid biosynthesis immortality G2 phase M phase meiosis exit from mitosis membrane polarization