| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-complex:3000023::positive |
| Nodes | AKT1 --+> CDK5 |
| References | 1 |
| Connectivity | 2 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i37 p35702 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/37/35702 |
| MedLine Reference | 12824184:1173 |
| Sentence | Cdk5 Is Involved in Neuregulin-induced Akt Phosphorylation and Activity in Cortical Neurons� If Cdk5 acts as a modulator of the PI3K/Akt signaling pathway via its phosphorylation of the ErbB3 receptor, then stimulation of the receptor by the addition of neuregulin should promote Cdk5 activity and ErbB3 phosphorylation. |