| Effect | negative |
|---|---|
| URN | urn:agi-ProtModification:in-urn:agi-llid:207:inout-urn:agi-go:0005899::negative |
| Nodes | AKT1 ---| insulin receptor |
| Modification Type | dephosphorylation |
| References | 5 |
| Connectivity | 2 |
| MedLine Reference | 10364160:1015 |
|---|---|
| Sentence | Activation of the insulin receptor leads to activation of other signaling molecules such as phosphoinositide-3-OH kinase (PI3K) and Ras and their downstream effectors, such as Akt/PKB and the MAP kinase cascade (Avruch 1998 ). |
| Journal | Genes & Dev |
| Journal Reference | v13 i11 p1438 (1999) |
| Journal Link | http://www.genesdev.org/cgi/content/full/13/11/1438 |
| MedLine Reference | 10364240:1080 |
|---|---|
| Sentence | Recent studies further indicate that Akt/PKB is required for insulin inactivation of GSK3eta in NIH-3T3 cells overexpressing insulin receptors ( 12 ), and in vitro experiments suggest that this is the result of Akt-catalyzed phosphorylation of serine 9 ( 13 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i25 p17934 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/25/17934 |
| MedLine Reference | 11349134:1342 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i30 p28348 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/30/28348 |
| Journal | J. Cell Biol |
|---|---|
| Journal Reference | v163 i2 p375 (2003) |
| Journal Link | http://www.jcb.org/cgi/content/full/163/2/375 |
| MedLine Reference | 11579209:12 |
|---|---|
| Sentence | Moreover, cotransfection of constitutively active Akt significantly inhibited the ability of wild-type PTP1B, but not PTP1B-S50A, to dephosphorylate the insulin receptor. |