| Effect | unknown |
|---|---|
| URN | urn:agi-ProtModification:in-urn:agi-llid:207:inout-urn:agi-go:0008385::unknown |
| Nodes | AKT1 ---> IkappaB kinase |
| Modification Type | phosphorylation |
| References | 9 |
| Connectivity | 2 |
| MedLine Reference | 11724787:1030 |
|---|---|
| Sentence | Protein kinase B (PKB/Akt ) has been shown to phosphorylate and activate IkappaB kinase ( 8 , 9 ), which in turn phosphorylates IkappaB. |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i5 p3109 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/5/3109 |
| MedLine Reference | 11416147:1390 |
|---|---|
| Sentence | AKT plays an important role in mediating antiapoptotic activities of growth factors and appears to do so in part by phosphorylating and affecting the activities of a number of proapoptotic proteins, including caspase 9, BAD, IkappaB kinase, GSK3eta, and FKHR ( 16 ; reviewed in references 33 to 35 ). |
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i14 p4713 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/14/4713 |
| MedLine Reference | 11705740:1357 |
|---|---|
| Sentence | Furthermore, Akt potentiates the activation of IKK, demonstrating cross talk between these two pathways. |
| Journal | Gastr. Liver Phys |
| Journal Reference | v281 i6 pG1357.htm (2001) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/281/6/G1357. |
| MedLine Reference | 11571285:1267 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i47 p43597 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43597 |
| MedLine Reference | 12063252:1028 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i34 p30935 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/34/30935 |
| MedLine Reference | 12871932:1261 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i41 p39583 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/41/39583 |
| MedLine Reference | 11134526:1186 |
|---|---|
| Journal | PNAS |
| Journal Reference | v98 i1 p247 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/1/247 |
| MedLine Reference | 10485711:5 |
|---|
| MedLine Reference | 15113757:7 |
|---|