| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:5728:out-urn:agi-go:0016342::negative:phosphorylation |
| Mechanism | phosphorylation |
| Nodes | PTEN ---| catenin |
| References | 4 |
| Connectivity | 2 |
| Journal | Cancer Res |
|---|---|
| Journal Reference | v62 i13 p3663 (2002) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/62/13/3663 |
| MedLine Reference | 12097272:1115 |
| Sentence | PTEN is shown to induce glycogen synthase kinase-3Ã?Â? activity, leading to increased phosphorylation of Ã?Â?-catenin and its subsequent degradation. |
| Journal | Cancer Res |
|---|---|
| Journal Reference | v63 i3 p674 (2003) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/63/3/674 |
| MedLine Reference | 12566313:1225 |
| Sentence | Perhaps significantly, Pten has been shown to negatively regulate the Ã?Â?-catenin/Lef-1 pathway by inhibiting the nuclear accumulation of Ã?Â?-catenin and activation of Lef-1 in a prostatic cell line (45) . |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i34 p30935 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/34/30935 |
| MedLine Reference | 12063252:1174 |
| Sentence | PTEN represses eta-catenin-mediated augmentation of AR activity by reducing nuclear eta-catenin protein. |
| Journal | J. Cell Biol |
|---|---|
| Journal Reference | v153 i6 p1161 (2001) |
| Journal Link | http://www.jcb.org/cgi/content/full/153/6/1161 |
| MedLine Reference | 11402061:1015 |