| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-complex:3000216::unknown |
| Nodes | MDM2 ---> hypoxia-inducible factor 1 |
| References | 2 |
| Connectivity | 2 |
| Journal | PNAS |
|---|---|
| Journal Reference | v99 i3 p1455 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/3/1455 |
| MedLine Reference | 11818530:1198 |
| Sentence | However, the actions of p19 ARF may also extend to the VHL pathway as implied by a role for p53 in modulating Mdm2- mediated degradation of HIF1 ( 41 ). |
| MedLine Reference | 15337760:8 |
|---|---|
| Sentence | It also indicates the important role of VEGF and HIF-1 in ovarian tumorigenesis and angiogenesis, which is mediated by the PI3K/AKT/HDM2 and AKT/p70S6K1 pathways in ovarian cancer cells. |