| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-complex:3000112::negative |
| Nodes | MDM2 ---| Phosphatidylinositol 3-kinase |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 14559824:0 |
|---|---|
| Sentence | The tumor suppressor PTEN has been associated with the cellular localization of MDM2 in regulation of apoptosis through inhibiting PI3k/Akt signaling. |
| MedLine Reference | 11504915:1125 |
|---|---|
| Sentence | Unphosphorylated serine 166 and serine 186 were not detected in IGF-1-stimulated cells, nor were phosphorylated parent peaks trapped from unstimulated cells, showing that activation of PI3-kinase/ Akt signaling increases Mdm2 phosphorylation. |