| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-complex:3000132::unknown |
| Nodes | MDM2 ---> proteasome |
| References | 5 |
| Connectivity | 2 |
| MedLine Reference | 11583595:1 |
|---|---|
| Sentence | Ubiquitination and the targeting of p53 for degradation by the proteasome are mediated by Mdm2 (mouse double minute clone 2), a negative regulatory partner of p53. |
| MedLine Reference | 12600196:1 |
|---|---|
| Sentence | Mdm2, a p53 inducible protein, negatively regulates p53 by inhibiting p53 transcriptional activity and promoting ubiquitin mediated proteasome degradation. |
| MedLine Reference | 12556559:1215 |
|---|
| MedLine Reference | 10207051:1299 |
|---|
| MedLine Reference | 11416144:1022 |
|---|