| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-complex:3000120::negative |
| Nodes | AKT1 ---| RNA polymerase II |
| References | 1 |
| Connectivity | 2 |
| MedLine Reference | 12438313:1192 |
|---|---|
| Sentence | Alternatively, we also found that Akt blocks the STAT3-mediated activation of the p21 waf1 gene by inhibiting the recruitment of CBP and the RNA polymerase II to the promoter, whereas the loading of STAT3 and its cofactor NcoA/SRC1a is not modified. |