| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-complex:3000132::positive |
| Nodes | AKT1 --+> proteasome |
| References | 1 |
| Connectivity | 2 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i24 p21843 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/24/21843 |
| MedLine Reference | 11923280:1284 |
| Sentence | Akt activation of Mdm2 may well account for the enhanced degradation of p53 by Akt, but these results do not rule out the possibility that Akt promotes p53 degradation through regulation of other targets, such as p19 ARF , p300, and the proteasome. |