| Effect | unknown |
|---|---|
| URN | urn:agi-ProtModification:in-urn:agi-llid:207:out-urn:agi-complex:3108385::unknown |
| Nodes | AKT1 ---> IkappaB kinase |
| Modification Type | phosphorylation |
| References | 6 |
| Connectivity | 2 |
| MedLine Reference | 11290748:1362 |
|---|---|
| Sentence | Ref-1 activates Akt, which phosphorylates I- kappaB kinase (IKK), which in turn phosphorylates IkappaBalpha, thereby accelerating its ubiquitination and degradation leading to NF-kappaB activation. |
| MedLine Reference | 11724787:1024 |
|---|---|
| Sentence | Protein kinase B (PKB/Akt ) has been shown to phosphorylate and activate IkappaB kinase ( 8 , 9 ), which in turn phosphorylates IkappaB. |
| MedLine Reference | 12063252:1021 |
|---|
| MedLine Reference | 15151944:4 |
|---|
| MedLine Reference | 11416147:1381 |
|---|
| MedLine Reference | 11134526:1185 |
|---|