| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-complex:3105899::negative:dephosphorylation |
| Mechanism | dephosphorylation |
| Nodes | AKT1 ---| insulin receptor |
| References | 3 |
| Connectivity | 2 |
| MedLine Reference | 10364160:1012 |
|---|---|
| Sentence | Activation of the insulin receptor leads to activation of other signaling molecules such as phosphoinositide-3-OH kinase (PI3K) and Ras and their downstream effectors, such as Akt/PKB and the MAP kinase cascade (Avruch 1998 ). |
| MedLine Reference | 11579209:12 |
|---|
| Sentence | Blocking insulin-dependent phosphorylation of AKT on Ser 473 with wortmannin failed to inhibit PLC 1 association with the IR ( Fig. 6 A). |
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