Regulation :


Effect	positive
URN	urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-complex:3000097::positive:phosphorylation
Mechanism	phosphorylation
Nodes	AKT1 --+> Nuclear factor NF kappa B
References	34
Connectivity	2


MedLine Reference	12505989:1016
Sentence	Similarly, an NF-kappaB activation pathway mediated by phosphoinositide 3-OH-kinase (PI 3-K) and the serine/threonine protein kinase Akt/PKB, has been linked to growth factor- induced NF-kappaB activation and anti-apoptotic responses ( Romashkova and Makarov, 1999 ).


MedLine Reference	10579998:1365
Sentence	Akt has also been shown to be both necessary and sufficient for the ability of both PDGF and TNF to induce NF-kappaB transcriptional activity (Khwaja 1999 ; Ozes et al. 1999 ; Romashkova and Makarov et al. 1999 ).


MedLine Reference	10652352:1237


MedLine Reference	10770953:1040


MedLine Reference	10811643:1021


MedLine Reference	11116146:1275


MedLine Reference	11259436:1026


MedLine Reference	11278812:1194


MedLine Reference	11290748:1041


MedLine Reference	11337489:1028


MedLine Reference	11410591:1011


MedLine Reference	11425860:1010


MedLine Reference	11435419:1026


MedLine Reference	11509575:1237


MedLine Reference	11571285:1017


MedLine Reference	11687577:1018


MedLine Reference	11724787:1029


MedLine Reference	11799112:1157


MedLine Reference	11884401:1030


MedLine Reference	11976320:1201


MedLine Reference	12052823:1008


MedLine Reference	12052830:1238


MedLine Reference	12145301:1022


MedLine Reference	12221085:1181


MedLine Reference	12446684:1030


MedLine Reference	12566451:1037


MedLine Reference	12649266:1324


MedLine Reference	12714587:1275


MedLine Reference	12816958:1212


MedLine Reference	12871932:1268


MedLine Reference	12881518:1258


MedLine Reference	12904304:1247


MedLine Reference	12952968:1054


MedLine Reference	11504779:1122