| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-complex:3000023::unknown |
| Nodes | TP53 ---> CDK5 |
| References | 7 |
| Connectivity | 2 |
| MedLine Reference | 11782425:1018 |
|---|---|
| Sentence | Finally, our data suggest that phosphorylated CREB recruits p53 tumor suppressor protein, modifies its transcriptional activity and increases the expression of p21 Waf1/Cip1 , a p53-regulated cyclin- dependent kinase inhibitor. |
| MedLine Reference | 12533509:1008 |
|---|---|
| Sentence | This physiologic response appears to trigger growth inhibition via activation of the tumor suppressor p53, which consequently up-regulates cyclin-dependent kinase (CDK) inhibitors p21, p19, and p16 (Brown et al. 1997 ; Lundberg et al. 2000 ). |
| MedLine Reference | 10581175:4 |
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| MedLine Reference | 7723404:2 |
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| MedLine Reference | 9820864:0 |
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| MedLine Reference | 9927805:8 |
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| MedLine Reference | 10373532:1019 |
|---|