| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-complex:3000216::unknown:phosphorylation |
| Nodes | AKT1 ---> hypoxia-inducible factor 1 |
| References | 4 |
| Connectivity | 2 |
| MedLine Reference | 11457733:1143 |
|---|---|
| Sentence | These observations suggest that PI3K and (by implication) its downstream target Akt affect angiogenesis by controlling the levels of HIF-1 . |
| MedLine Reference | 11834720:1227 |
|---|---|
| Sentence | However, Laughner et al 30 have recently demonstrated that the HIF-1 induction caused by stimulating the PI3K/Akt/FRAP pathway, is because of increased protein synthesis and is not associated with an increased HIF-1 mRNA level or with increased HIF-1 protein stability. |
| MedLine Reference | 11859074:1191 |
|---|
| MedLine Reference | 12052884:1328 |
|---|