| URN | urn:agi-Expression:inout-urn:agi-llid:7157:out-urn:agi-complex:3000216::unknown |
|---|---|
| Nodes | TP53 ---> hypoxia-inducible factor 1 |
| References | 2 |
| Connectivity | 2 |
| Effect | unknown |
| MedLine Reference | 11156418:1261 |
|---|---|
| Sentence | It has been shown recently that loss of function mutations in tumor suppressor genes encoding PTEN (38) , VHL (39) and p53 (40 , 41) result in increased expression of HIF-1 and VEGF. |
| MedLine Reference | 12727853:1032 |
|---|---|
| Sentence | However, other studies have not found a link between p53 and thrombospondin-1 expression in glioma cell lines or in glioma tumors (30) but have found that p53 expression regulates expression of GD-AIF (31) , of BAI1 (32) , and of HIF- 1 (33) . |