hypoxia-inducible factor 1 IgG catenin IkappaB kinase Phosphatidylinositol 3-kinase platelet-derived growth factor RNA polymerase II CDK5 Nuclear factor NF kappa B RNA polymerase II catenin insulin receptor IL1 IkappaB kinase proteasome insulin receptor PIP3 PTEN MDM2 TP53 AKT1