| URN | urn:agi-MolSynthesis:inout-urn:agi-llid:4193:out-urn:agi-llid:7157::positive |
|---|---|
| Nodes | MDM2 --+> TP53 |
| References | 2 |
| Connectivity | 2 |
| Effect | positive |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v22 i15 p5308 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/15/5308 |
| MedLine Reference | 12101226:1123 |
| Sentence | p19ARF and Mdm2 contribute to p53 accumulation. |
| Journal | PNAS |
|---|---|
| Journal Reference | v99 i5 p3099 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/5/3099 |
| MedLine Reference | 11867746:1155 |
| Sentence | Posttranslational modifications of p53 and Mdm-2, after gamma-irradiation or oxidative stress, result in their diminished association followed by decreased p53 ubiquitination and degradation, thus allowing accumulation of biologically active p53 (reviewed in refs. 2 and 33 ). |