| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-llid:4193::negative |
| Nodes | TP53; MDM2; FHIT |
| References | 2 |
| Connectivity | 3 |
| MedLine Reference | 15313915:3 |
|---|---|
| Sentence | Furthermore, we found that this synergistic inhibition of tumor cell growth corresponded with the FHIT-mediated inactivation of MDM2, which thereby blocked the association of MDM2 with p53, thus stabilizing the p53 protein. |
| MedLine Reference | 15152193:6 |
|---|---|
| Sentence | Growth inhibition, presumably through suppression of rRNA production in the nucleolus, facilitates translocation of L11 to the nucleoplasm, thus activating p53 through inhibiting HDM2. |