| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-llid:7157::unknown |
| Nodes | MDM2 ---> TP53 |
| References | 15 |
| Connectivity | 2 |
| MedLine Reference | 15246006:0 |
|---|---|
| Sentence | MDM2 is an important negative regulator of the tumor suppressor protein p53 which regulates the expression of many genes including MDM2. |
| MedLine Reference | 15154850:1 |
|---|---|
| Sentence | Degradation of p53 is mediated by the ubiquitin ligase MDM2 (mouse double minute protein) and is also reported to be regulated by CBP/p300. |
| MedLine Reference | 12085228:0 |
|---|---|
| Sentence | The small basic protein p14ARF, encoded by one of the alternative transcripts from the human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour suppressor protein. |
| MedLine Reference | 14559824:6 |
|---|
| MedLine Reference | 15295102:6 |
|---|
| MedLine Reference | 12753723:4 |
|---|
| MedLine Reference | 15326223:4 |
|---|
| MedLine Reference | 15169778:1 |
|---|
| MedLine Reference | 15358376:0 |
|---|
| MedLine Reference | 15056666:8 |
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| MedLine Reference | 7753547:2 |
|---|
| MedLine Reference | 15452548:0 |
|---|
| MedLine Reference | 15308643:1 |
|---|
| MedLine Reference | 9371494:3 |
|---|
| MedLine Reference | 9824166:1 |
|---|