| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-llid:7157::negative |
| Nodes | MDM2 ---| TP53 |
| References | 11 |
| Connectivity | 2 |
| MedLine Reference | 14707282:3 |
|---|---|
| Sentence | MDM2 functions as an E3 ubiquitin ligase to degrade p53. |
| MedLine Reference | 14707283:1 |
|---|---|
| Sentence | MDM2, a p53-specific E3 ubiquitin ligase, is the principal cellular antagonist of p53, acting to limit the p53 growth-suppressive function in unstressed cells. |
| MedLine Reference | 15246006:0 |
|---|---|
| Sentence | MDM2 is an important negative regulator of the tumor suppressor protein p53 which regulates the expression of many genes including MDM2. |
| MedLine Reference | 15004525:2 |
|---|
| MedLine Reference | 15257544:2 |
|---|
| MedLine Reference | 15314174:5 |
|---|
| MedLine Reference | 10891494:1 |
|---|
| MedLine Reference | 14757842:0 |
|---|
| MedLine Reference | 10438849:6 |
|---|
| MedLine Reference | 10626788:7 |
|---|
| MedLine Reference | 15024700:3 |
|---|