| Effect | unknown |
|---|---|
| URN | urn:agi-ProtModification:in-urn:agi-llid:4193:out-urn:agi-llid:7157::unknown |
| Nodes | MDM2 ---> TP53 |
| Modification Type | acetylation |
| References | 5 |
| Connectivity | 2 |
| MedLine Reference | 11861384:1269 |
|---|---|
| Sentence | High levels of mdm-2 may prevent the DNA-damaging signal from phosphorylating p53. |
| MedLine Reference | 12426395:1105 |
|---|---|
| Sentence | Together, these results indicate that MDM2 promotes the interaction between HDAC1 and p53 and forms a ternary complex, allowing efficient p53 deacetylation. |
| MedLine Reference | 11358489:1017 |
|---|
| MedLine Reference | 12068014:1036 |
|---|
| MedLine Reference | 11070080:1120 |
|---|