Binding :

URN urn:agi-Binding:inout-urn:agi-llid:7157:inout-urn:agi-llid:4193:
Nodes TP53 ---- MDM2
References 218
Connectivity 2

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Sentence Recent evidence suggests that p60 can also be expressed at high levels in the absence of apoptosis. 20 The complexity of the p53-MDM2 regulatory loop is further increased by the recent finding of another protein from the CDKN2A locus on chromosome 9q21 that binds to the p53-MDM2 complex.

MedLine Reference 11159535:1006
Sentence To further investigate the role of the p53/MDM2 complex in these BL cells, as well as in other lymphoid cells that do not overexpress MDM2, this study used antisense oligodeoxynucleotides directed either against mdm2 or against p53.

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Sentence In the absence of stress, growth suppressive and proapoptotic activity of p53 is inhibited by MDM2 which binds p53 and negatively regulates its activity and stability.

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