| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-llid:4193::positive |
| Mechanism | dephosphorylation |
| Nodes | TP53 --+> MDM2 |
| References | 33 |
| Connectivity | 2 |
| Journal | Cell Sci |
|---|---|
| Journal Reference | v116 i20 p4077 (1997) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/116/20/4077 |
| MedLine Reference | 12972501:1086 |
| Sentence | Whereas p53 alone is sufficient for the induction of p21 and Mdm2 , the induction of the apoptotic genes PERP, Bax and Noxa requires p53 together with p63 and p73. |
| Journal | Cell |
|---|---|
| Journal Reference | v90 i6 p1097 (1997) |
| Journal Link | http://www.cell.com/cgi/content/full/90/6/1097 |
| Journal | Cell |
|---|---|
| Journal Reference | v91 i3 p325 (1997) |
| Journal Link | http://www.cell.com/cgi/content/full/91/3/325 |
| Journal | Cell |
|---|---|
| Journal Reference | v101 i7 p753 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/101/7/753 |
| Journal | Cell |
|---|---|
| Journal Reference | v101 i7 p753 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/101/7/753 |
| Journal | Endocrinology |
|---|---|
| Journal Reference | v139 i11 p4688 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/11/4688 |
| MedLine Reference | 9794481:1013 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v274 i47 p33747 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/47/33747 |
| MedLine Reference | 10559267:1029 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i19 p15598 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/19/15598 |
| MedLine Reference | 11278953:1038 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i49 p48872 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/49/48872 |
| MedLine Reference | 14523002:1154 |
| Journal | J. Exp. Med |
|---|---|
| Journal Reference | v190 i10 p1375 (1999) |
| Journal Link | http://www.jem.org/cgi/content/full/190/10/1375 |
| Journal | J. Exp. Med |
|---|---|
| Journal Reference | v190 i10 p1375 (1999) |
| Journal Link | http://www.jem.org/cgi/content/full/190/10/1375 |
| Journal | J. Exp. Med |
|---|---|
| Journal Reference | v190 i10 p1375 (1999) |
| Journal Link | http://www.jem.org/cgi/content/full/190/10/1375 |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v20 i4 p1291 (2000) |
| Journal Link | http://mcb.asm.org/cgi/content/full/20/4/1291 |
| MedLine Reference | 10648614:1009 |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v22 i19 p6797 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/19/6797 |
| MedLine Reference | 12215537:1016 |
| Journal | PNAS |
|---|---|
| Journal Reference | v94 i20 p11037 (1997) |
| Journal Link | http://www.pnas.org/cgi/content/full/94/20/11037 |
| MedLine Reference | 9380755:1036 |
| MedLine Reference | 10493513:1040 |
|---|---|
| Sentence | In addition, phosphorylation of p53 by DNA-protein kinase that is induced by ionizing radiation prevents MDM-2 from inhibiting p53- dependent transactivation (42) . |
| MedLine Reference | 10626788:1184 |
|---|---|
| Sentence | Thus, p53 phosphorylation may inhibit the efficient ubiquitination of p53 by residual MDM2 protein. |
| MedLine Reference | 10919634:1176 |
|---|
| MedLine Reference | 11156428:1172 |
|---|
| MedLine Reference | 11245472:1098 |
|---|
| MedLine Reference | 11507071:1212 |
|---|
| MedLine Reference | 11731421:1035 |
|---|
| MedLine Reference | 12873982:1140 |
|---|
| MedLine Reference | 11323398:1015 |
|---|
| MedLine Reference | 12082016:1034 |
|---|
| MedLine Reference | 10099830:1161 |
|---|
| MedLine Reference | 10593650:1160 |
|---|
| MedLine Reference | 10202144:1133 |
|---|
| MedLine Reference | 10648615:2 |
|---|
| MedLine Reference | 10082513:5 |
|---|
| MedLine Reference | 12668979:1 |
|---|
| MedLine Reference | 15313915:3 |
|---|
| MedLine Reference | 15519799:10 |
|---|