Regulation :

Effect positive
URN urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:cell%20survival::positive
Nodes MDM2 --+> cell survival
References 8
Connectivity 2

MedLine Reference 11278272:1294
Sentence In addition, a strong and constitutive expression of double minute 2 (MDM2) protein, which facilitates G 1 to S phase transition by activation of E2F-1 and enhances cell survival by suppressing p53 function, was observed in multiple myeloma ( 72 , 73 ).

MedLine Reference 10902970:10
Sentence MDM2 expression was the most useful independent factor for overall survival (p=0.0001).

MedLine Reference 12393983:8

MedLine Reference 12604636:7

MedLine Reference 9292533:0

MedLine Reference 9632782:4

MedLine Reference 15218947:11

MedLine Reference 10688665:1223