| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:fate::unknown |
| Nodes | TP53 ---> fate |
| References | 7 |
| Connectivity | 2 |
| Journal | Endocrinology |
|---|---|
| Journal Reference | v144 i5 p1832 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/5/1832 |
| MedLine Reference | 12697689:1208 |
| Sentence | As previously reported in glioma cells ( 42 ), calcitriol up-regulated the expression of GADD45, another important p53-dependent regulator of cell fate ( 48 ), in betaTC3 cells. |
| MedLine Reference | 10497185:1016 |
|---|---|
| Sentence | The tumor suppressor p53 is one of the key proteins affecting the fate of cells exposed to external insults; activation of p53 leads to apoptosis or cell cycle arrest. |
| MedLine Reference | 12101184:1015 |
|---|---|
| Sentence | Inactivation of wild-type p53 resulted in a transition of the cellular response to adriamycin treatment from replicative senescence to delayed apoptosis, demonstrating that p53 plays an integral role in the fate of breast tumor cells treated with DNA- damaging agents. |
| MedLine Reference | 10436055:1012 |
|---|
| MedLine Reference | 9275177:0 |
|---|
| MedLine Reference | 15123817:1 |
|---|
| MedLine Reference | 9751765:1145 |
|---|