| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:proteolysis::positive |
| Nodes | MDM2 --+> proteolysis |
| References | 3 |
| Connectivity | 2 |
| MedLine Reference | 10228155:1163 |
|---|---|
| Sentence | E6-AP and Mdm2 function as ubiquitin ligases which target p53 and result in proteolysis of the ubiquitinated product; however, they are not SCF-type ubiquitin ligases (Scheffner et al ., 1993 , 1995 ; Hatakeyama et al ., 1997 ; Honda et al ., 1997 ). |
| MedLine Reference | 11309410:1203 |
|---|---|
| Sentence | Mdm-2 modulates p53 by binding and promoting the ubiquitination and subsequent proteolysis of p53 ( Fuchs et al. 1998 ). |
| MedLine Reference | 9632782:1230 |
|---|