| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:s%20phase::negative |
| Nodes | TP53 ---| s phase |
| References | 11 |
| Connectivity | 2 |
| MedLine Reference | 11289144:1352 |
|---|---|
| Sentence | Because there are some data indicating that p53 and p21 may act in S phase and G 2 -M transition too (for review, see Ref. 58 ), we examined whether they were affected in our system. |
| MedLine Reference | 11306504:1029 |
|---|---|
| Sentence | The tumor suppressor genes p53 and pRB are negative regulators of the cell cycle involved in controlling the transition from G 0 /G 1 to S phase. |
| MedLine Reference | 11522645:1235 |
|---|
| MedLine Reference | 11980662:1031 |
|---|
| MedLine Reference | 12234990:1219 |
|---|
| MedLine Reference | 12874009:1308 |
|---|
| MedLine Reference | 11285191:1089 |
|---|
| MedLine Reference | 12082017:1209 |
|---|
| MedLine Reference | 11864911:1051 |
|---|
| MedLine Reference | 11884368:1090 |
|---|
| MedLine Reference | 10619603:2 |
|---|---|
| Sentence | While E2F proteins are implicated in promoting the S phase of the cell cycle, p53 has the potential to arrest cells in G1 phase and thereby prevent entry into S phase. |