| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:assemble::positive |
| Nodes | MDM2 --+> assemble |
| References | 4 |
| Connectivity | 2 |
| MedLine Reference | 12615721:1185 |
|---|---|
| Sentence | By contrast, infection of these cells with a virus encoding Mdm2 increased their efficiency of colony formation (data not shown), consistent with the ability of Mdm2 to counter the effects of p53 in primary MEFs and increase their proliferative rate (22) . |
| MedLine Reference | 12750288:1029 |
|---|---|
| Sentence | Mdm2 promotes breast cancer formation in murine models (28) and overexpression of hdm2 in human tumors such as sarcomas, in which the hdm2 gene is amplified (29) , results in a reduced rate of p53 mutation in these cancers. |
| MedLine Reference | 11013216:1062 |
|---|
| MedLine Reference | 11927554:1259 |
|---|