| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:response%20to%20DNA%20damage::negative |
| Nodes | MDM2 ---| response to DNA damage |
| References | 8 |
| Connectivity | 2 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.1 |
| MedLine Reference | 10856296:1014 |
| Sentence | While Raf-induced Mdm2 can attenuate p53 accumulation in response to DNA damage in p19 ARF null MEFs, we detect no attenuation of p53 response in wild-type MEFs upon Raf activation ( Figure 6A and Figure 6B ). |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.1 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.2 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.2 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.2 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.2 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321 |
| Sentence | While Raf-induced Mdm2 can attenuate p53 accumulation in response to DNA damage in p19 ARF null MEFs, we detect no attenuation of p53 response in wild-type MEFs upon Raf activation ( Figure 6A and Figure 6B ). |
|---|
| Sentence | Because p19 ARF is not expressed, the elevated Mdm2 protein is functionally active and attenuates p53 accumulation in response to DNA damage. |
|---|