| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:DNA%20damage%20recognition::positive |
| Nodes | TP53 --+> DNA damage recognition |
| References | 32 |
| Connectivity | 2 |
| MedLine Reference | 12231554:1219 |
|---|---|
| Sentence | Wild-type p53 arrests cell proliferation and may retain cells with DNA damage in the G1 phase of the cell cycle. |
| MedLine Reference | 10446957:1009 |
|---|---|
| Sentence | In addition, crucial evidence indicating that DNA-PK controls the transactivation of p53 following DNA damage was reported quite recently. |
| MedLine Reference | 10537312:1029 |
|---|
| MedLine Reference | 10646856:1014 |
|---|
| MedLine Reference | 10676633:1015 |
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| MedLine Reference | 10728664:1092 |
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| MedLine Reference | 10749144:1113 |
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| MedLine Reference | 10766157:1035 |
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| MedLine Reference | 10919643:1132 |
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| MedLine Reference | 11059759:1079 |
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| MedLine Reference | 11280729:1018 |
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| MedLine Reference | 11559575:1022 |
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| MedLine Reference | 11929828:1025 |
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| MedLine Reference | 12019172:1046 |
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| MedLine Reference | 12067998:1022 |
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| MedLine Reference | 12438258:1202 |
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| MedLine Reference | 12460929:1514 |
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| MedLine Reference | 12670900:1018 |
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| MedLine Reference | 10069459:1087 |
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| MedLine Reference | 10469621:1108 |
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| MedLine Reference | 10590213:1018 |
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| MedLine Reference | 11285191:1184 |
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| MedLine Reference | 11756229:1022 |
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| MedLine Reference | 12082016:1023 |
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| MedLine Reference | 12082025:1031 |
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| MedLine Reference | 10437915:1020 |
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| MedLine Reference | 10547070:1024 |
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| MedLine Reference | 11864911:1029 |
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| MedLine Reference | 7614713:1111 |
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| MedLine Reference | 10082513:0 |
|---|---|
| Sentence | The tumor suppressor p53 plays a key role in inducing G1 arrest and apoptosis following DNA damage. |
| MedLine Reference | 12792779:3 |
|---|
| MedLine Reference | 10611322:0 |
|---|