Regulation :

Effect unknown
URN urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:mitogenesis::unknown
Nodes MDM2 ---> mitogenesis
References 26
Connectivity 2

MedLine Reference 10537276:1166
Sentence Given that MDM2 can inhibit the TGF-eta-induced cell cycle arrest (3) , the data presented here may suggest a possible mechanism of how this can be achieved.

MedLine Reference 10919661:1054
Sentence Thus, elevated mdm2 levels also result in abrogation of p53-mediated cell cycle arrest and apoptosis (40...42) .

MedLine Reference 11013216:1008

MedLine Reference 10614665:1264

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MedLine Reference 15644444:4
Sentence MDM2 has multiple p53-independent functions modulating cell cycle and transcriptional events.

MedLine Reference 15720190:3