Regulation :


Effect	negative
URN	urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:G1-S%20transition::negative
Nodes	TP53 ---\| G1-S transition
References	36
Connectivity	2


MedLine Reference	10733508:1185
Sentence	In the second pathway p53-dependent checkpoints involving the p53, p21(WAF1/CIP1), p27(KIP1), and p57(KIP2) proteins regulate G 1 /S transition.


MedLine Reference	10811129:1101
Sentence	The induction of p53 also results in the transcriptional activation of other cell cycle regulatory genes, such as p21 WAF-1 leading to arrest of the cell cycle at the G 1 -S checkpoint (24) .


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