| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:protein%20degradation::unknown |
| Nodes | MDM2 ---> protein degradation |
| References | 5 |
| Connectivity | 2 |
| MedLine Reference | 11245472:1098 |
|---|---|
| Sentence | MDM2 is transcriptionally induced by p53 and works as a feedback inhibitor by promoting p53 protein degradation and inhibiting p53 transcriptional activities (45 , 46 , 47) . |
| MedLine Reference | 12750254:1410 |
|---|---|
| Sentence | Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. |
| MedLine Reference | 10980197:1064 |
|---|
| MedLine Reference | 12753897:3 |
|---|
| MedLine Reference | 11739723:1187 |
|---|