| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:assemble::negative |
| Nodes | TP53; assemble; HIPK2 |
| References | 8 |
| Connectivity | 3 |
| Journal | AJRCMB |
|---|---|
| Journal Reference | v27 i2 p186 (2002) |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/27/2/186 |
| MedLine Reference | 12151310:1134 |
| Journal | Cell |
|---|---|
| Journal Reference | v88 i3 p323 (1997) |
| Journal Link | http://www.cell.com/cgi/content/full/88/3/323 |
| Journal | EMBO |
|---|---|
| Journal Reference | v21 i10 p2373 (2002) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/21/10/2373 |
| MedLine Reference | 12006490:1049 |
| MedLine Reference | 10646845:1120 |
|---|---|
| Sentence | Therefore, loss of IGFBP-3 could contribute to the development of colonic adenomas that retain wild-type p53 function through suppression of p53-dependent apo-ptotic signals, allowing aberrant cell survival and tumor formation. |
| MedLine Reference | 10359010:1033 |
|---|---|
| Sentence | The p53 protein, originally identified as a cellular nuclear phosphoprotein bound to the large transforming antigen of the SV40 DNA virus (23 , 24) , plays a role in control of cell cycle progression through G 1 into S phase, DNA repair, differentiation, tumor formation, and apoptosis (25 , 26 , 27) . |
| MedLine Reference | 9468185:1013 |
|---|
| MedLine Reference | 11925430:9 |
|---|---|
| Sentence | HIPK2 potentiated the inhibition of colony formation by p73 and p53. |
| MedLine Reference | 15720184:2 |
|---|