| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:senescence::positive |
| Nodes | TP53 --+> senescence |
| References | 24 |
| Connectivity | 2 |
| Journal | Cell Phys |
|---|---|
| Journal Reference | v281 i3 pC941 (2001) |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/281/3/C941 |
| MedLine Reference | 11502571:1027 |
| Sentence | The p53 gene is responsible for control of the cell cycle, apoptosis, and the onset of cellular senescence ( 7 , 13 , 51 ) and may play a role in the regulation of normal intestinal mucosal growth. |
| Journal | Cell Sci |
|---|---|
| Journal Reference | v116 i20 p4077 (1997) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/116/20/4077 |
| MedLine Reference | 12972501:1034 |
| Journal | Cell |
|---|---|
| Journal Reference | v91 i5 p649 (1997) |
| Journal Link | http://www.cell.com/cgi/content/full/91/5/649 |
| Journal | EMBO |
|---|---|
| Journal Reference | v21 i16 p4338 (2002) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/21/16/4338 |
| MedLine Reference | 12169636:1034 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i26 p23630 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/26/23630 |
| MedLine Reference | 12714585:1257 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v273 i44 p29156 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/44/29156 |
| MedLine Reference | 9786925:1022 |
| Journal | J. Cell Biol |
|---|---|
| Journal Reference | v157 i3 p429 (2002) |
| Journal Link | http://www.jcb.org/cgi/content/full/157/3/429 |
| MedLine Reference | 11369650:1021 |
|---|---|
| Sentence | The p53 gene encodes for a protein with 393 amino acids, which acts as a multifunctional transcription factor involved in cell cycle arrest, apoptosis, cell differentiation, replication, DNA repair, senescence, and maintenance of genomic stability (reviewed in references 6 and 7). |
| MedLine Reference | 10383161:1035 |
|---|---|
| Sentence | Levels of p53 have been found to increase at late passage in human fibroblasts, putatively contributing to senescence growth arrest (11 , 21) . |
| MedLine Reference | 10919634:1173 |
|---|
| MedLine Reference | 11912168:1008 |
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| MedLine Reference | 12097273:1546 |
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| MedLine Reference | 12208764:1199 |
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| MedLine Reference | 12670900:1382 |
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| MedLine Reference | 12750285:1035 |
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| MedLine Reference | 12782571:1188 |
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| MedLine Reference | 12782591:1280 |
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| MedLine Reference | 12810676:1549 |
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| MedLine Reference | 12873977:1168 |
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| MedLine Reference | 12941806:1113 |
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| MedLine Reference | 10437915:1020 |
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| MedLine Reference | 11331249:1038 |
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| MedLine Reference | 9546379:1020 |
|---|
| MedLine Reference | 15379854:0 |
|---|