| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:differentiation::unknown |
| Nodes | TP53 ---> differentiation |
| References | 57 |
| Connectivity | 2 |
| Journal | Cell Sci |
|---|---|
| Journal Reference | v116 i20 p4077 (1997) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/116/20/4077 |
| MedLine Reference | 12972501:1024 |
| Sentence | In addition, p53 contributes to cellular processes such as differentiation, DNA repair and angiogenesis, which also appear to be vital for tumor suppression (reviewed by Vogt Sionov and Haupt, 1999 ). |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v273 i44 p29156 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/44/29156 |
| MedLine Reference | 9786925:1022 |
| MedLine Reference | 11369650:1021 |
|---|---|
| Sentence | The p53 gene encodes for a protein with 393 amino acids, which acts as a multifunctional transcription factor involved in cell cycle arrest, apoptosis, cell differentiation, replication, DNA repair, senescence, and maintenance of genomic stability (reviewed in references 6 and 7). |
| MedLine Reference | 9414264:1151 |
|---|---|
| Sentence | The tumor suppressor gene p53 has many effects on cell growth and differentiation and is often viewed as a gate-keeper to enter the cell cycle. |
| MedLine Reference | 10626796:1155 |
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| MedLine Reference | 10850421:1029 |
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