| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:transformation::unknown |
| Nodes | TP53 ---> transformation |
| References | 44 |
| Connectivity | 2 |
| Journal | Cancer Res |
|---|---|
| Journal Reference | v59 i17 p4247 (1999) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/59/17/4247 |
| MedLine Reference | 10485466:1017 |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v20 i10 p3377 (2000) |
| Journal Link | http://mcb.asm.org/cgi/content/full/20/10/3377 |
| MedLine Reference | 10779326:1009 |
| MedLine Reference | 10646842:1015 |
|---|---|
| Sentence | Many mutant forms of p53 have been reported to promote neoplastic transformation (7) , and the importance of the p53 gene in determining susceptibility to cancer has been exemplified by its role in the pathogenesis of the Li-Fraumeni syndrome (8) . |
| MedLine Reference | 11059788:1011 |
|---|---|
| Sentence | In similar experiments, cotransfection of wt p53 or 14/19 p53 resulted in significant inhibition of oncogenic transformation in rat embryo fibroblast mediated by an activated ras plus c- myc , adenovirus E1A , or human papillomavirus E7 oncogenes. |
| MedLine Reference | 11085543:1010 |
|---|
| MedLine Reference | 11181448:1012 |
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| MedLine Reference | 10547071:1032 |
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| MedLine Reference | 11568302:1058 |
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| MedLine Reference | 10842176:1238 |
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| MedLine Reference | 11836241:1009 |
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| MedLine Reference | 1616957:3 |
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| MedLine Reference | 1333524:4 |
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| MedLine Reference | 7914423:6 |
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| MedLine Reference | 7947385:0 |
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| MedLine Reference | 10549095:7 |
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| MedLine Reference | 10779327:0 |
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| MedLine Reference | 12021785:0 |
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| MedLine Reference | 12101418:2 |
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| MedLine Reference | 12902991:1 |
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| MedLine Reference | 7630643:6 |
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| MedLine Reference | 8806689:0 |
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| MedLine Reference | 8821956:1 |
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| MedLine Reference | 8909732:4 |
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| MedLine Reference | 9050995:8 |
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| MedLine Reference | 9167046:12 |
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| MedLine Reference | 9579543:4 |
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| MedLine Reference | 12482984:1028 |
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| MedLine Reference | 11756653:1021 |
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| MedLine Reference | 15334538:0 |
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| Sentence | Human tumor suppressor protein p53 plays a major role in the cell cycle, orchestrating a number of important genes involved in cell-cycle control and apoptosis, and seems to be one of the most important molecules protecting cells from malignant transformation. |
| MedLine Reference | 15467748:2 |
|---|
| MedLine Reference | 15678851:2 |
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