| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:apoptosis::negative |
| Nodes | MDM2 ---| apoptosis |
| References | 13 |
| Connectivity | 2 |
| Journal | Cancer Res |
|---|---|
| Journal Reference | v60 i21 p6184 (2000) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/60/21/6184 |
| MedLine Reference | 11085543:1154 |
| Journal | Cell |
|---|---|
| Journal Reference | v101 i7 p753 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/101/7/753 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.1 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.2 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.2 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321 |
| MedLine Reference | 11159535:1080 |
|---|---|
| Sentence | These results indicate that mdm2 AS induces apoptosis of the cells that contain MDM2 protein (whether this protein is overexpressed or not) and wild-type p53 (whether this protein accumulates after AS treatment or not) but have no effects on the viability of the cells that contain MDM2 and mutated p53 or MDM2 and no p53. |
| MedLine Reference | 11964305:1124 |
|---|---|
| Sentence | In addition, increased resistance to apoptosis induced by doxorubicin in MDM2-transfected cells was detected by examining the activation of caspase-3 and the cleavage of its substrate PARP. |
| MedLine Reference | 9292533:1011 |
|---|
| MedLine Reference | 10766163:1148 |
|---|
| MedLine Reference | 10919661:1054 |
|---|
| MedLine Reference | 10202144:1043 |
|---|
| MedLine Reference | 10891494:4 |
|---|---|
| Sentence | We found that Mdm2 expression rescues the temperature-sensitive phenotype of tsBN462 cells, as shown by activation of cell cycle-regulated gene promoters (B-myb, cyclin A, and cdc25C), increased cell growth and DNA synthesis, and inhibition of apoptosis. |
| MedLine Reference | 15720190:3 |
|---|