| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:g1phase::negative |
| Nodes | TP53 ---| g1 phase |
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| Sentence | Wild-type p53 arrests cell proliferation and may retain cells with DNA damage in the G1 phase of the cell cycle. |
| MedLine Reference | 11964308:1011 |
|---|---|
| Sentence | We observed several important cellular characteristics associated with this treatment, including elevation of cAMP, induction of p53 and p21 WAF1/CIP1 proteins, G 1 and G 2 /M cell cycle arrest, and increased apoptosis. |
| MedLine Reference | 10344760:1128 |
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| MedLine Reference | 12876306:1257 |
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| MedLine Reference | 15077186:2 |
|---|---|
| Sentence | In inducible systems and in cells expressing the endogenous protein, expression of 72P wild-type p53 results in a predominant G1 arrest, with only a minor apoptosis, at drug concentrations causing extensive apoptosis in cells expressing the 72R wild-type variant. |
| MedLine Reference | 10082513:0 |
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| MedLine Reference | 15685034:4 |
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