| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:drug%20resistance::positive |
| Nodes | TP53 --+> drug resistance |
| References | 11 |
| Connectivity | 2 |
| MedLine Reference | 10213491:1117 |
|---|---|
| Sentence | Expression of DNA topoisomerase II and glutathione S -transferases (8) , p53, BCL2, and the BAX gene families (19) have also been found to play an important role in the development of drug resistance in a variety of tumors. |
| MedLine Reference | 10590234:1017 |
|---|---|
| Sentence | In addition, p53 may regulate DNA repair directly, regulate multidrug resistance or regulate other drug resistance mechanisms ( 9 ... 23 ). |
| MedLine Reference | 11483519:1217 |
|---|
| MedLine Reference | 11507088:1030 |
|---|
| MedLine Reference | 10735894:1 |
|---|
| MedLine Reference | 12015983:0 |
|---|
| MedLine Reference | 12533045:12 |
|---|
| MedLine Reference | 14623330:4 |
|---|
| MedLine Reference | 12897129:1026 |
|---|
| MedLine Reference | 10531402:1036 |
|---|
| MedLine Reference | 15492510:7 |
|---|---|
| Sentence | Inhibition of p53 by siRNA or by the temperaturesensitive mutation reduced G(2)/M accumulation and drug resistance of BCR/ABL cells. |