Understanding Pathway Assist Biological Interaction Networks (BIN)

In Pathway Assist, a biological interaction network is a set of ‘nodes’ interconnected by links called ‘controls’.  The ‘nodes’, in this case, refers to biological molecules and ‘controls’ refers to interactions between nodes. 

An example of a Pathway Assist Biological Interaction Network is shown below:


 
Biological Interaction Network


There are 8 different types of ‘nodes’ and each is represented in a unique graphical form:

nodes_legend

Each ‘node’ is clickable to view the annotation information.  This includes the molecule name, alias, description, HUGO ID, Swiss Prot ID, MGI ID, OMIM ID, Locuslink ID, RGD ID, Unigene ID, Gene Ontolology terms, and organism name.

‘Controls’ are represented as arrows with different colors in the network, each representing a type of control/interaction.  The 9 ‘control’ types are shown below:

controls_legend

 The dots on each 'control' arrow is clickable to obtain the description of an interaction and the relevant MedLine articles.