The
p53 protein is known to regulate the
expression of genes involved in critical cell processes such as the
induction of apoptosis, cell cycle arrest and DNA repair. What is
known about p53 regulatory pathways have been presented in other public
databases and are listed below in the section
'Pathway Maps Online' together with
other p53-related pathways. A core regulatory network for p53
have also been presented in
Aguda
et al. (2005) and the authors have
pointed out the relationship between the p53 regulatory pathways to
cell death and
cell survival decisions.
Additionally, the significance of these pathways to cell fate is
determined by the presence of negative and positive feedback
loops. The interaction between positive feedback loops and
between positive and negative feedback loops also seem to play a
role. The first section
'Feedback
Loops in the p53 Core Regulatory Network' is an attempt to
present the feedback loops and provide interaction evidence from
Pathway
Studio. It is also discussed in more detail in
Aguda
et al.
(2005) and is based on a recent review article by
Harris
and Levine (2005).
