Nucleotide Positions:			Codon Positions:
	to			to
	Mutation Type:			Mutation Effect Type:
	A:T>C:G A:T>G:C A:T>T:A CC Tandem Complex Deletion G:C>A:T G:C>C:G G:C>T:A Insertion Tandem			Frameshift Intronic Missense NA Nonsense Other Silent Splice
	Locations of TFs binding to the P53 DNA Molecule:			Locations of SNPs:
	ATF3 BCL6 E2F4 EGR1 ETS1 ETS2 HOXA5 JUN/FOS MYC/MAX NFIC NFKB1/RELA P53 PAX2 PAX5 PAX8 SP1 USF1 YY1			AnyYes
	Features on the P53 DNA molecule:			Domains on the P53 Protein:
	CpG Splice Site			DNA-binding Domain [DNA-binding] Nuclear Export Signal (C-terminal) [Motif] Nuclear Export Signal (N-terminal) [Motif] Nuclear Localisation Signal I [Motif] Nuclear Localisation Signal II [Motif] Nuclear Localisation Signal III [Motif] Oligomerization Domain [Oligomerization] Proline-rich Domain [Proline-rich] Transactivation Domain [Transactivation]
	Structural Motifs on the P53 Protein:			Tumor Origin:
	C-term C-term/NLS C-term/tetramerisation L1/S/H2 L2/L3 N-term N-term/Transactivation N-term/Transactivation/NES NA NDBL/beta-sheets SH3-like/Pro-rich			metastasis (bone marrow) metastasis (bone) metastasis (brain) metastasis (breast) metastasis (colon) metastasis (liver) metastasis (LN) metastasis (lung) metastasis (neck) metastasis (NOS) metastasis (pericard) metastasis (peritoneum) metastasis (pleura) metastasis (skin) metastasis (soft tissue) NA primary recurrent secondary
	Topography:			Morphology:
	- ACCESSORY SINUSES ADRENAL GLAND ANUS AND ANAL CANAL BASE OF TONGUE BLADDER BONES, JOINTS AND ARTICULAR CARTILA... BONES, JOINTS AND ARTICULAR CARTILA... BRAIN BREAST BRONCHUS AND LUNG CERVIX UTERI COLON COLORECTUM, NOS CONNECTIVE, SUBCUTANEOUS AND Other ... CORPUS UTERI DIGESTIVE ORGANS, NOS ESOPHAGUS EYE AND ADNEXA FEMALE GENITAL ORGANS, NOS FLOOR OF MOUTH GALLBLADDER GUM HEAD&NECK, NOS HEART, MEDIASTINUM, AND PLEURA HEMATOPOIETIC AND RETICULOENDOTHELI... HYPOPHARYNX KIDNEY LARYNX LIP (excludes Skin of lip ) LIVER AND INTRAHEPATIC BILE DUCTS LYMPH NODES MENINGES NASAL CAVITY AND MIDDLE EAR NASOPHARYNX OROPHARYNX OTHER AND ILL-DEFINED DIGESTIVE ORG... Other AND ILL-DEFINED SITES Other AND ILL-DEFINED SITES IN LIP,... OTHER AND ILL-DEFINED SITES WITHIN ... OTHER AND UNSPECIFIED FEMALE GENITA... OTHER AND UNSPECIFIED MAJOR SALIVAR... Other AND UNSPECIFIED MALE GENITAL ... Other AND UNSPECIFIED PARTS OF BILI... Other AND UNSPECIFIED PARTS OF MOUT... Other AND UNSPECIFIED PARTS OF TONG... OTHER AND UNSPECIFIED URINARY ORGAN... OTHER ENDOCRINE GLANDS AND RELATED ... OVARY PALATE PANCREAS PAROTID GLAND PENIS PERIPHERAL NERVES AND AUTONOMIC NER... PLACENTA PROSTATE GLAND PYRIFORM SINUS RECTOSIGMOID JUNCTION RECTUM RENAL PELVIS RETROPERITONEUM AND PERITONEUM SKIN (excludes Skin of vulva, Skin ... SMALL INTESTINE SPINAL CORD, CRANIAL NERVES, AND Ot... STOMACH TESTIS THYMUS THYROID GLAND TONSIL TRACHEA UNKNOWN PRIMARY SITE URETER UTERUS, NOS VAGINA VULVA			- Acinar cell carcinoma Acute leukemia, NOS Acute megakaryoblastic leukemia Acute monocytic leukemia Acute myeloid leukemia with maturation Acute myeloid leukemia, M6 type Acute myeloid leukemia, minimal differentiation Acute myeloid leukemia, NOS Acute myelomonocytic leukemia Adenocarcinoma in situ in adenomatous polyp Adenocarcinoma, diffuse type (C16._) Adenocarcinoma, endocervical type Adenocarcinoma, intestinal type (C16._) Adenocarcinoma, metastatic, NOS Adenocarcinoma, NOS Adenofibroma, NOS (C56.9) Adenoid cystic carcinoma Adenoma, NOS Adenomatous polyp, NOS Adenomatous polyposis coli (C18._) Adenosarcoma Adenosquamous carcinoma Adrenal cortical adenoma, clear cell (C74.0) Adrenal cortical adenoma, NOS (C74.0) Adrenal cortical carcinoma (C74.0) Adult T-cell leukemia/lymphoma (HTLV-1 positive) Aggressive fibromatosis Aggressive NK-cell leukemia Alveolar rhabdomyosarcoma Ameloblastoma, NOS Anaplastic large cell lymphoma, T cell and null ce Angioimmunoblastic T-cell lymphoma Angiomyoma Apocrine adenocarcinoma Askin tumor Astroblastoma (C71._) Astrocytoma, anaplastic (C71._) Astrocytoma, NOS (C71._) Atypical adenoma Atypical choroid plexus papilloma (C71.5) Atypical fibrous histiocytoma B-cell chronic lymphocytic leukemia/small lymphocy Barrett's esophagus Basal cell carcinoma, nodular (C44._) Basal cell carcinoma, NOS (C44._) Basaloid carcinoma (C21.1) Basosquamous carcinoma (C44._) Bowen disease (C44._) Brenner tumor, malignant (C56.9) Brenner tumor, NOS (C56.9) Bronchiolo-alveolar adenocarcinoma (C34._) Burkitt cell leukemia Burkitt lymphoma, NOS Canalicular adenoma Cancer Carcinoid tumor of uncertain malignant potential Carcinoid tumor, NOS (except of Appendix M-8240/1) Carcinoma in pleomorphic adenoma (C07._, C08._) Carcinoma in situ, NOS Carcinoma, anaplastic, NOS Carcinoma, metastatic, NOS Carcinoma, NOS Carcinoma, undifferentiated, NOS Carcinosarcoma, NOS Central neurocytoma Cholangiocarcinoma (C22.1, C24.0) Chondroblastic osteosarcoma (C40._, C41._) Chondrosarcoma, NOS (C40._, C41._) Choriocarcinoma, NOS Choroid plexus carcinoma (C71.5) Choroid plexus papilloma, NOS (C71.5) Chronic myeloid leukemia, NOS Chronic myelomonocytic leukemia, NOS Clear cell adenocarcinofibroma (C56.9) Clear cell adenocarcinoma, NOS Clear cell sarcoma of kidney (C64.9) Clear cell sarcoma, NOS (except of Kidney M-8964/3 Combined hepatocellular carcinoma and cholangiocar Comedocarcinoma, noninfiltrating (C50._) Comedocarcinoma, NOS (C50._) Cribriform carcinoma in situ (C50._) Cribriform carcinoma, NOS Cutaneous T-cell lymphoma, NOS (C44._) Dedifferentiated chondrosarcoma (C40._, C41._) Dermatofibroma, NOS (C44._) Dermatofibrosarcoma, NOS (C44._) Ductal carcinoma in situ, solid type (C50._) Dysgerminoma Dysplasia, mild Dysplasia, moderate Dysplasia, NOS Dysplasia, severe Dysplastic nevus (C44._) Eccrine adenocarcinoma (C44._) Embryo fibroblasts Embryonal rhabdomyosarcoma, NOS Embryonal sarcoma Endometrioid adenocarcinoma, NOS Ependymoma, anaplastic (C71._) Ependymoma, NOS (C71._) Epithelial tumor, benign Essential thrombocythemia Ewing sarcoma Fibrillary astrocytoma (C71._) Fibroadenoma, NOS (C50._) Fibrosarcoma, NOS Fibrosis, NOS Follicular adenocarcinoma, NOS (C73.9) Follicular adenoma (C73.9) Follicular lymphoma, grade 1 Follicular lymphoma, grade 2 Follicular lymphoma, grade 3 Follicular lymphoma, NOS Ganglioneuroblastoma Ganglioneuroma Gemistocytic astrocytoma (C71._) Germinoma Giant cell and spindle cell carcinoma Giant cell carcinoma Giant cell glioblastoma (C71._) Giant cell tumor of soft parts, NOS Glandular intraepithelial neoplasia, grade III Glioblastoma, NOS (C71._) Glioma, malignant (C71._) Gliomatosis cerebri (C71._) Gliosarcoma (C71._) Glomus tumor, NOS Goblet cell carcinoid Granulosa cell tumor, malignant (C56.9) Hairy cell leukemia (C42.1) Hemangioendothelioma, NOS Hemangiopericytoma, NOS Hemangiosarcoma Hepatoblastoma (C22.0) Hepatocellular adenoma (C22.0) Hepatocellular carcinoma, NOS (C22.0) Hepatoid adecarcinoma Hidrocystoma (C44._) Histiocytoma, NOS Hodgkin lymphoma, NOS Hydatidiform mole, NOS (C58.9) Hyperplasia, glandular Hyperplasia, NOS Infiltrating basal cell carcinoma, NOS (C44._) Infiltrating duct carcinoma, NOS (C50._) Infiltrating ductular carcinoma (C50._) Intraductal carcinoma and lobular carcinoma in sit Intraductal carcinoma, noninfiltrating, NOS Intraductal papillary adenocarcinoma with invasion Intraductal papillary-mucinous adenoma (C25._) Intraductal papillary-mucinous carcinoma, non inva Kaposi sarcoma Keloid Keratoacanthoma, NOS Keratosis, actinic Keratosis, NOS Klatskin tumor (C22.1, C24.0) Large cell carcinoma, NOS Leiomyoma, NOS Leiomyosarcoma, NOS Lentigo maligna melanoma (C44._) Leucoplakia, NOS Leukemia, NOS Lipoma, NOS Liposarcoma, NOS Lobular carcinoma, NOS (C50._) Lymphoid leukemia, NOS Lymphomatoid papulosis (C44._) Malignant fibrous histiocytoma Malignant histiocytosis Malignant lymphoma, large B-cell, diffuse, immunob Malignant lymphoma, large B-cell, diffuse, NOS Malignant lymphoma, mixed small and large cell, di Malignant lymphoma, non-Hodgkin, NOS Malignant lymphoma, NOS Malignant lymphoma, small B lymphocytic, NOS Malignant melanoma, NOS Malignant peripheral nerve sheath tumor Malignant peripheral nerve sheath tumor with rhabd Malignant rhabdoid tumor Malignant teratoma, intermediate Mantle cell lymphoma Marginal zone B-cell lymphoma, NOS Mature T-cell lymphoma, NOS Medullary carcinoma, NOS Medulloblastoma, NOS (C71.6) Medulloepithelioma, NOS Melanoma in situ Meningioma, malignant Meningioma, NOS Merkel cell carcinoma (C44._) Mesodermal mixed tumor Mesothelioma, malignant Metaplasia Metaplastic carcinoma, NOS Mixed cell adenocarcinoma Mixed glioma (C71._) Mixed liposarcoma Mucinous adenocarcinoma Mucinous cystadenocarcinoma, non-invasive (C25._) Mucinous cystadenocarcinoma, NOS (C56.9) Mucinous cystic tumor of borderline malignancy (C5 Mucoepidermoid carcinoma Mullerian mixed tumor (C54._) Multifocal superficial basal cell carcinoma (C44._ Multiple myeloma (C42.1) Mycosis fungoides (C44._) Myelodysplastic syndrome with 5q deletion Myelodysplastic syndrome, NOS Myeloid leukemia, NOS Myelosclerosis with myeloid metaplasia Myoepithelioma Myofibroblastic tumor, NOS Myxoid liposarcoma Neoplasm, benign Neoplasm, NOS Nephroblastoma, NOS (C64.9) Neurilemoma, malignant Neurilemoma, NOS Neuroblastoma, NOS Neuroendocrine carcinoma, NOS Neuroepithelioma, NOS Neurofibroma, NOS NK/T-cell lymphoma, nasal and nasal-type Nodular melanoma (C44._) Non-small cell carcinoma (C34._) Nonencapsulated sclerosing carcinoma (C73.9) Normal tissue Oat cell carcinoma (C34._) Oligodendroglioma, anaplastic (C71._) Oligodendroglioma, NOS (C71._) Osteochondroma (C40._, C41._) Osteosarcoma, NOS (C40._, C41._) Paget's disease and intraductal carcinoma of breas Paget's disease, mammary (C50._) Papillary adenocarcinoma, NOS Papillary carcinoma in situ Papillary carcinoma, follicular variant (C73.9) Papillary carcinoma, NOS Papillary cystadenocarcinoma, NOS (C56.9) Papillary serous cystadenocarcinoma (C56.9) Papillary transitional cell carcinoma (C67._) Papilloma, NOS (except Papilloma of bladder M-8120 Periosteal osteosarcoma (C40._, C41._) Peripheral neuroectodermal tumor Pheochromocytoma, malignant (C74.1) Pheochromocytoma, NOS (C74.1) Phyllodes tumor, benign (C50._) Phyllodes tumor, malignant (C50._) Pigmented nevus, NOS (C44._) Pilocytic astrocytoma (C71._) Plasma cell leukemia (C42.1) Plasmacytoma, NOS Pleomorphic adenoma Pleomorphic carcinoma Pleomorphic liposarcoma Pleomorphic rhabdomyosarcoma, adult type Pleomorphic xanthoastrocytoma (C71._) Pleuropulmonary blastoma Polycythemia vera Polyp, NOS Precursor B-cell lymphoblastic leukemia Precursor cell lymphoblastic leukemia, NOS Precursor cell lymphoblastic lymphoma, NOS Precursor T-cell lymphoblastic leukemia Primitive neuroectodermal tumor, NOS (C71._) Prolymphocytic leukemia, NOS Pseudosarcomatous carcinoma Pterygium Pulmonary blastoma (C34._) Renal cell carcinoma, NOS (C64.9) Renal cell carcinoma, sarcomatoid (C64.9) Rhabdomyosarcoma, NOS Sarcoma, NOS Scirrhous adenocarcinoma Sebaceous adenocarcinoma (C44._) Secretory carcinoma of breast (C50._) Seminoma, NOS (C62._) Serous adenocarcinofibroma Serous cystadenocarcinoma, NOS (C56.9) Serous cystadenoma, borderline malignancy (C56.9) Serous surface papillary carcinoma (C56.9) Serous surface papillary tumor of borderline malig Serrated adenoma (C18._) Sex cord-gonadal stromal tumor, NOS Sezary syndrome Signet ring cell carcinoma Small cell carcinoma, intermediate cell Small cell carcinoma, NOS Solid carcinoma, NOS Solitary fibrous tumor, malignant Spindle cell carcinoma, NOS Spindle cell sarcoma Splenic marginal zone-B-cell lymphoma (C42.2) Squamous cell carcinoma in situ with questionable Squamous cell carcinoma in situ, NOS Squamous cell carcinoma, adenoïd Squamous cell carcinoma, keratinizing, NOS Squamous cell carcinoma, large cell, nonkeratinizi Squamous cell carcinoma, NOS Squamous cell carcinoma, spindle cell Stromal sarcoma, NOS Superficial spreading melanoma (C44._) Sweat gland adenocarcinoma (C44._) Synovial sarcoma, NOS T-cell large granular lymphocytic leukemia Teratocarcinoma Teratoma with malignant transformation Teratoma, benign Teratoma, malignant, NOS Teratoma, NOS Therapy-related acute myeloid leukemia, NOS Therapy-related myelodysplastic syndrome Thymic carcinoma, NOS (C37.9) Thymoma, NOS (C37.9) Transitional cell carcinoma in situ Transitional cell carcinoma, NOS Trichilemmocarcinoma (C44._) Trichilemmoma (C44._) Trichoepithelioma (C44._) Tubular adenocarcinoma Tubular adenoma, NOS Tubulovillous adenoma, NOS Tumor cells, NOS Tumor, metastatic Urothelial papilloma, NOS Villous adenoma, NOS Waldenstrom macroglobulinemia (C42.0) Yolk sac tumor
	Sample Source:
	Any Germline Somatic Both